Ultrasound evaluation of peripheral nerves of the lower limb in diabetic peripheral neuropathy.

PURPOSE: Comparative evaluation of the cross-sectional area (CSA) of the sural and tibial nerves using ultrasound in diabetic peripheral neuropathy (DPN). METHOD: This study involved 210 participants divided into 3 groups: type 2 diabetics with DPN, type 2 diabetics without DPN, and controls. Ultrasound evaluation of the sural and tibial nerves was done using a 5-17 MHz linear transducer. The CSA of both the nerves was recorded in both lower limbs. Nerve conduction studies (NCS) were also done in all diabetic patients. RESULTS: There were 70 participants in each group. All the three groups were gender-matched and no significant difference was observed between CSA values of the sural and tibial nerves between males and females and also in right and left lower limbs within a group. The sural nerve CSA was significantly higher in the DPN group than in diabetic patients without DPN and controls. The sensitivity of the sural nerve CSA was higher than the tibial nerve with a cut-off value of 4.41 mm2 for CSA of the sural nerve. CONCLUSION: The sural nerve CSA at the superior border of lateral malleolus can be used for screening DPN. With well-established cut-off values may result in early initiation of the therapy even in NCS negative cases, thus reducing the morbidity associated with the disease. Ultrasound could be used as a first diagnostic tool for detection of DPN which can be followed by NCS in cases where ultrasound is non-diagnostic.

Dysplasia Epiphysealis Hemimelica (Trevor Disease) of the Patella: A Case Report.

CASE: We report a rare case of dysplasia epiphysealis hemimelica in an 11-year-old male child involving the patella. The patient noticed swelling in the right knee 6 months before presentation. On evaluation, there was a mass lesion originating from superior pole of the patella extending into the suprapatellar pouch. On opening the knee joint, it was found to be mainly cartilaginous in nature. Surgical excision of the mass was carried out. CONCLUSION: Trevor disease should be considered in the differential diagnosis of a mass originating from the patella in children. The recommended treatment is complete excision of the mass.

Evaluation of plantar fascia using high-resolution ultrasonography in clinically diagnosed cases of plantar fasciitis.

PURPOSE: The aim of this study was to assess the efficacy of high-resolution ultrasonography in the assessment of plantar fascia in individuals with heel pain, before and after treatment. MATERIAL AND METHODS: This study was conducted from 2016 to 2019, during which time 44 clinically diagnosed patients of plantar fasciitis were compared to 50 normal volunteers. There were 25 males and 25 females in the control group and 42 females and two males in the study group. Thirty-eight patients had unilateral disease, and six patients had bilateral disease. The thickness of the plantar fascia was measured just anterior to its calcaneal attachment using ultrasonography. Body mass index (BMI) was also calculated in both groups. RESULTS: The plantar fascia was 2-4 mm thick in the control group whereas it was > 4 mm thick in 48 heels in the study group. With cut-off of > 4 mm as diagnostic of plantar fasciitis, this study had a sensitivity of 96%, specificity of 100%, and accuracy of 98%. BMI was increased in 60% of female patients. All patients were treated with local infiltration of corticosteroid. In 37/42 patients (43 heels) who had improved clinically, the thickness of plantar fascia was reduced to < 4 mm when assessed after six weeks of corticosteroid injection. CONCLUSIONS: Diagnosis of plantar fasciitis can be easily verified by ultrasonography with plantar fascia thickness > 4 mm being suggestive of plantar fasciitis. Ultrasound can also be used to evaluate treatment response. Ultrasono-graphy helps the clinician in confirming the diagnosis of plantar fasciitis and also in assessing the response to treatment.

Limb Salvage Using Liquid Nitrogen-Treated Tumour-Bearing Autograft: A Single Institutional Experience of 10 Patients.

BACKGROUND: Many reconstruction methods have evolved to offer limb salvage surgery (LSS) to patients with musculoskeletal sarcomas. It can be achieved using endoprosthesis or biological reconstruction methods like allograft or autograft or a combination of both. In carefully selected patients, resected bone can be recycled and reimplanted after sterilisation using methods like irradiation, autoclaving, pasteurisation or liquid nitrogen. METHODS: From 2010 to 2016, 10 patients with primary musculoskeletal sarcoma underwent limb salvage surgery (LSS) by wide resection of the tumour and reconstruction using recycled autograft treated with liquid nitrogen. Intercalary resection was carried out in six patients and intra-articular in four. The resected bone was dipped in liquid nitrogen for 25 min, thawed at room temperature for 15 min followed by dipping in vancomycin-mixed saline for 10 min. The recycled bone was re-implanted into its original site and stabilised with internal fixation. RESULTS: At a mean follow-up period of 39.6 months (range 6-97 months), all patients had a good function (mean functional score of 80%) with no evidence of local recurrence in the re-implanted bone or otherwise. Union was achieved at 15 of the 16 osteotomy sites with a mean union time of 5.2 months (range 4-7 months) without any additional surgical interventions. In none of the patient, augmentation with vascularised/non-vascularised fibula was done. No complication like fracture of the autograft, implant failure or deep/superficial infection was reported in any patient. CONCLUSION: Recycled tumour-bearing autograft after treatment with liquid nitrogen is an anatomical, cost-effective, relatively simpler and reliable technique for reconstruction of bone defect after resection in selective primary musculoskeletal sarcoma patients.

Accuracy of high-resolution ultrasonography in establishing the diagnosis of carpal tunnel syndrome.

BACKGROUND: The aim of this study was to evaluate the accuracy of high-resolution ultrasonography in the diagnosis of carpal tunnel syndrome (CTS). METHODS: It included 50 patients with signs and symptoms suggestive of CTS and 50 individuals as control group. Cross-sectional area of median nerve at the inlet of carpal tunnel was measured in control as well as symptomatic group by ultrasonography. In addition, nerve conduction studies (NCS) were carried out in the symptomatic group. Radiologists performing the ultrasonography were blinded to the results of NCS. Sensitivity, specificity and accuracy of ultrasonography and NCS in the diagnosis of CTS were calculated and compared. RESULTS: In control group, cross-sectional area of the median nerve ranged between 5 and 7.3 mm2 , whereas in the symptomatic group it varied from 8.4 to 16.5 mm2 . It was >9 mm2 in 47 patients. With a cut-off of 9 mm2 , sensitivity, specificity and accuracy of ultrasonography in diagnosing CTS were 95%, 100% and 97%, respectively. NCS was diagnostic of CTS in 48 (96%) patients. CONCLUSION: Ultrasonographic examination gives similar results to NCS in establishing diagnosis of CTS and can be used as a screening modality with further use of NCS in cases where ultrasonography is non-diagnostic.

Bronchial asthma with ABPA presenting as PTE.

Allergic bronchopulmonary aspergillosis (ABPA), as a complication of asthma, is rare in children. The persistent and poorly-controlled asthma leading to cor pulmonale is not uncommon in adults but rarely described in the pediatric age group. Here, we report a case of asthma and ABPA complicated by pulmonary thrombo-embolism and cor pulmonale. To the best of our knowledge, such association has never been reported in the pediatric age group.

Aceclofenac-induced acute tubulointerstitial nephritis in a patient with diabetes.

We describe a case of a 40-year-old lady diabetic and hypertensive, who presented with increasing fatigue and decreased physical endurance attributable to deterioration in renal function. The renal biopsy revealed drug-induced acute tubulointerstitial nephritis and the chronology of the events suggested the aetiology to be a recent intake of aceclofenac for knee pain. The patient improved with oral corticosteroids and the renal functions returned to baseline in 3 weeks. We did not come across a case of aceclofenac-induced acute tubulointerstitial nephritis on extensive electronic search of literature. This is probably the first case report of acute tubulointerstitial nephritis associated with the use of aceclofenac, a newer potent non-steroidal anti-inflammatory drug.

Maternal serum second trimester screening for chromosomal disorders and neural tube defects in a government hospital of North India.

OBJECTIVE: Down syndrome (DS) has major resource implications especially in developing countries being third most important cause of mental handicap. Maternal serum screening for chromosomal aneuploidies and neural tube defects (NTDs) is practiced worldwide in many countries and has been integrated into mainstream health care, while it is gradually gaining momentum in Asian countries. METHODS: This prospective cohort study was carried out in pregnant women undergoing triple screening test between January 2007 and December 2010 after informed consent. Biomarkers alpha-fetoprotein, human-chorionic-gonadotropin and unconjugated-estriol were tested, and risk of pregnancy being affected with DS, Edward's syndrome or NTDs were calculated. Screen-positive patients were referred for detailed ultrasonography and confirmatory amniocentesis. Follow-up record was maintained until delivery. RESULTS: Of 7400 pregnant women enrolled, 419(5.7%) were screen-positive, including 339 positive for DS, two for trisomy 18, and 62 for NTDs. Total eight cases of DS were eventually diagnosed in the population (prevalence of DS = 1 : 925), seven of which were detected in utero following diagnostic evaluation for positive serum screen (DR of DS screen = 87.5%). Total five cases of NTD were observed, yielding NTD prevalence of 0.67/1000. CONCLUSIONS: Triple screening in the second trimester is reasonably effective for the detection of major chromosomal defects and NTDs, and can be implemented successfully also in India.

Massive cerebral air embolism on ante mortem CT head following pneumothorax in a child with pneumonia.

Cerebral air embolism (CAE) is a rarely reported complication of a common condition like pneumothorax, presenting with deterioration of sensorium and cardiovascular instability. We report a case of 3-year-old male who developed pneumothorax after positive pressure ventilation followed by deterioration of sensorium. CT head revealed massive CAE.